Mastra vs Microsoft AutoGen

as AI assistants see them, week of 2026-09-14

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Mastra and Microsoft AutoGen land in a virtual tie overall, each scoring 8 out of 100 across AI assistants. Mastra edges ahead on raw mentions, named in 12 of 71 answers versus AutoGen's 10 of 71, and comes out on top head-to-head, leading in 5 questions to AutoGen's 3, with 12 ties. Mastra shows up most for developer framework and multi-agent system questions, while AutoGen leans on open-source framework mentions, appearing in all 3 of 3 answers there. Both go unmentioned for voice agents, non-technical founders, and self-hosted setups.

Head to head

metric	Mastra	Microsoft AutoGen
score	8	8
questions won	9	4

By assistant

Mastra

assistant	score	named in, this week	usual spot, this week
ChatGPT	5	10% of answers	#6.5
Claude	18	40% of answers	#9.1
Gemini	0	0% of answers
Perplexity	7	11% of answers	#4.5

Microsoft AutoGen

assistant	score	named in, this week	usual spot, this week
ChatGPT	6	10% of answers	#5.5
Claude	9	20% of answers	#9.5
Gemini	12	17% of answers	#3.5
Perplexity	7	11% of answers	#5.0

Where they differ

Only Mastra gets named for

What's the best tool for building multi-agent systems?
What's the best platform for an agency building AI agents for clients?
What's the best platform to build AI agents that use MCP tools?
What's the best tool to build an AI agent that browses the web and does research?
What's the best platform to build and deploy AI agents for a startup?

Only Microsoft AutoGen gets named for

nothing exclusive

More comparisons

Not sold on either?

Scores count how often each assistant names a product, weighted by position. How the score works · Full AI agent builders leaderboard